IMMUNE CHECKPOINT INHIBITORS PLUS DEBULKING SURGERY FOR PATIENTS WITH METASTATIC RENAL CELL CARCINOMA: CLINICAL OUTCOMES AND IMMUNOLOGICAL CORRELATES OF A PROSPECTIVE PILOT TRIAL

Abstract Surgical removal 1073spx of primary tumors reverses tumor-mediated immune suppression in pre-clinical models with metastatic disease.However, how cytoreductive surgery in the metastatic setting modulates the immune responses in patients, especially in the context of immune checkpoint therapy (ICT), is not understood.We report the first pro

BackgroundRetinal detachment often leads to a severe and permanent loss of vision and its therapeutic management remains to this day exclusively surgical.We have used surgical specimens to perform a differential analysis of the transcriptome of human retinal tissues following detachment in order to identify new potential pharmacological targets tha

Division of labor and task specialization explain the success of human and insect societies.Social insect colonies are characterized by division of labor, with workers specializing in brood care early and foraging later in here life.Theory posits that this task switching requires shifts in responsiveness to task-related cues, yet experimental evide

The syntactic information of a dependency tree is an essential feature in relation extraction studies.Traditional dependency-based relation extraction methods can be categorized into here hard pruning methods, which aim to remove unnecessary information, and soft pruning methods, which aim to utilize all lexical information.However, hard pruning ha